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Planning on EPA Virtual Tissue Modeling Systems (VTM) to produce quantitative cellular, tissue and phenotypic responses
Citation:
Knudsen, T. Planning on EPA Virtual Tissue Modeling Systems (VTM) to produce quantitative cellular, tissue and phenotypic responses. Presented at STAR Organotypic Culture Models (OCM) for Predictive Toxicology Progress Review, RTP, NC, May 22 - 23, 2018. https://doi.org/10.23645/epacomptox.6949970
Impact/Purpose:
Presentation at 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Review in RTP, NC May 2018
Description:
Chemical regulation under the Frank R. Lautenberg Chemical Safety for the 21st Century Act of 2016 requires affirmation of ‘low’ and ‘high’ priority substances based on unreasonable risk to vulnerable subpopulations and lifestages. New approach methods (NAMs) based on in vitro data and in silico models can test the majority of chemicals in commerce within a decade but interpretation remains a challenge, especially for complex processes such as developmental toxicity and cancer. OCM platforms (eg, biomimetic embryo) in parallel with ABM platforms (eg, virtual embryo) can work together seamlessly in translating HTS data through cellular networks to predicted phenotype.
URLs/Downloads:
DOI: Planning on EPA Virtual Tissue Modeling Systems (VTM) to produce quantitative cellular, tissue and phenotypic responses
2018_VTM_OVERVIEW.PDF (PDF, NA pp, 614.877 KB, about PDF)